Browse result page of B3Pdb

The total number entries retrieved from this search are 64, scroll left/right for detailed information.
B3pdbIDPEPTIDE NAMEPEPTIDE SEQUENCE (1-letter)PEPTIDE SEQUENCE (3-letter)N-TERMINAL MODIFICATIONC-TERMINAL MODIFICATION CHEMICAL MODIFICATIONPEPTIDE LENGTHPEPTIDE CONFORMATIONPEPTIDE NATURESOURCE/ORIGIN OF PEPTIDESMILESCELL LINEIn vitro CONCENTRATIONIn vitro METHODIn vitro RESULTANIMAL MODELIn vivo CONCENTRATIONIn vivo MODE OF DELIVERYIn vivo METHODIn vivo RESULTACTIONTRANSPORT TYPESUBCELLULAR LOCALISATIONCOMBINATIONPHYSICAL CONDITIONRESPONSERESULTLABELPMID
b3pdb_0047C-TN-APNPsCAQKCysAlaGlnLysNANANA4LinearNAChemically synthesizedN[C@@]([H])(CS)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CCCCN)C(=O)OhCMEC/D3 and NHA cellsNATEM imagingResponsive to thrombin cleavage, reduced the cytotoxicity of Tat-NR2B9c, and increased BBB permeabilC57BL6 miceNAIntravenous Dynamic light scatteringBetter circulation time, better targeting ability and penetrating efficiency to the injured brain, a Treatment reduced the injury size NA NA Combined with Tat-NR2B9c Traumatic brain injury NA NA NA 31213815
b3pdb_0048CC-TN-APNPsCCAQKCysCysAlaGlnLysNANANA5LinearNAChemically synthesizedN[C@@]([H])(CS)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CCCCN)C(=O)OhCMEC/D3 and NHA cellsNATEM imagingResponsive to thrombin cleavage, reduced the cytotoxicity of Tat-NR2B9c, and increased BBB permeabilC57BL6 miceNAIntravenous Dynamic light scatteringBetter circulation time, better targeting ability and penetrating efficiency to the injured brain, a Treatment reduced the injury size NA NA Combined with Tat-NR2B9c Traumatic brain injury NA NA NA 31213815
b3pdb_0050DeltorphanYAFDVVGTyr-(D)Ala-Phe-Asp-Val-Val-Gly-NH2NAAmide group is attachedNA7LinearNAChemically synthesizedN[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)NCC(=O)ONANANANAC57BL6 miceNAIntravenous Confocal microscopyPresence of engineered nano particles within the brain parenchyma with particular focus on hippocamp Opioid-derived peptides featured by specific helix-like conformation as possible ligands to engineer NA CNS parenchyma Comined NA NA NA NA 32479916
b3pdb_0065Ang-2CTFFYGGSRGKRNNFKTEECysThrPhePheTyrGlyGlySerArgGlyLysArgAsnAsnPheLysThrGluGluNANANA19LinearNAChemically synthesizedN[C@@]([H])(CS)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)NCC(=O)NCC(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)ONANANANAC57BL6 mice1 mg/mLIntraperitonealFluorescent microscopyLocalization of the nanoparticle within the brain cells, highlighting in particular the neuron accum Brain-targeted PLGA nanoparticles were able to cross the BBB and accumulated in neuronal cells, thus Transcytosis NA Conjugated to poly(lactic-co-glycolic acid) (PLGA) NA NA NA NA 31963430
b3pdb_0066HAVN1SHAVSSSerHisAlaValSerSerNANANA6CyclicNAChemically synthesizedN[C@@]([H])(CO)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CO)C(=O)ONANANANAC57BL6 miceNAIntracerebral ventricularMass SpectromteryIt is able to deliver an IRdye800CW-labeled IgG monoclonal antibody into the brain. Synthesized novel cyclic peptides are able efectively modulate the BBB to enhance the delivery of mA NA NA Combined with monoclonal antibody NA NA NA NA 31683745
b3pdb_0067HAVN2SHAVSSerHisAlaValSerNANANA5CyclicNAChemically synthesizedN[C@@]([H])(CO)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CO)C(=O)ONANANANAC57BL6 miceNAIntracerebral ventricularMass SpectromteryIt is able to deliver an IRdye800CW-labeled IgG monoclonal antibody into the brain. Synthesized novel cyclic peptides are able efectively modulate the BBB to enhance the delivery of mA NA NA Combined with monoclonal antibody NA NA NA NA 31683745
b3pdb_0068Linear ADTHAVTPPVSHAVThrProProValSerHisAlaValAcetylaed at N-terminalAmide group is attached at C-terminalNA8LinearNAChemically synthesizedN[C@@]([H])([C@]([H])(O)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C(C)C)C(=O)ONANANANAC57BL6 miceNAIntracerebral ventricularMass SpectromteryIt is able to deliver an IRdye800CW-labeled IgG monoclonal antibody into the brain. Synthesized novel cyclic peptides are able efectively modulate the BBB to enhance the delivery of mA NA NA Combined with monoclonal antibody NA NA NA NA 31683745
b3pdb_0069Cyclic ADTHAVTPPVSHAVThrProProValSerHisAlaValNANANA8CyclicNAChemically synthesizedN[C@@]([H])([C@]([H])(O)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C(C)C)C(=O)ONANANANAC57BL6 miceNAIntracerebral ventricularMass SpectromteryIt is able to deliver an IRdye800CW-labeled IgG monoclonal antibody into the brain. Synthesized novel cyclic peptides are able efectively modulate the BBB to enhance the delivery of mA NA NA Combined with monoclonal antibody NA NA NA NA 31683745
b3pdb_0070ADTC5CDTPPVCCysAspThrProProValCysNAAmide group is attached at C-terminalNA7CyclicNAChemically synthesizedN[C@@]([H])(CS)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CS)C(=O)ONANANANAC57BL6 miceNAIntracerebral ventricularMass SpectromteryIt is able to deliver an IRdye800CW-labeled IgG monoclonal antibody into the brain. Synthesized novel cyclic peptides are able efectively modulate the BBB to enhance the delivery of mA NA NA Combined with monoclonal antibody NA NA NA NA 31683745
b3pdb_0080BVDO2DmtNmeAFS-NH2H-Dmt-Nme-D-Ala-Phe-Ser-NH2MethylationAmidationNA4TetrapeptideCationicNANANANANANAC57BL6 mice5 mg/KgIntravenous Hot water tail flick test70% maximum possible effect after 5 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0081BVDO2DmtNmeAFS-NH3H-Dmt-Nme-D-Ala-Phe-Ser-NH2MethylationAmidationNA4TetrapeptideCationicNANANANANANAC57BL6 mice5 mg/KgIntravenous Hot water tail flick test100% maximum possible effect after 15 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0082BVDO2DmtNmeAFS-NH4H-Dmt-Nme-D-Ala-Phe-Ser-NH2MethylationAmidationNA4TetrapeptideCationicNANANANANANAC57BL6 mice5 mg/KgIntravenous Hot water tail flick test100% maximum possible effect after 30 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0083BVDO2DmtNmeAFS-NH5H-Dmt-Nme-D-Ala-Phe-Ser-NH2MethylationAmidationNA4TetrapeptideCationicNANANANANANAC57BL6 mice5 mg/KgIntravenous Hot water tail flick test100% maximum possible effect after 60 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0084BVDO2DmtNmeAFS-NH6H-Dmt-Nme-D-Ala-Phe-Ser-NH2MethylationAmidationNA4TetrapeptideCationicNANANANANANAC57BL6 mice5 mg/KgIntravenous Hot water tail flick test100% maximum possible effect after 120 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0085BVDO2DmtNmeAFS-NH7H-Dmt-Nme-D-Ala-Phe-Ser-NH2MethylationAmidationNA4TetrapeptideCationicNANANANANANAC57BL6 mice1 mg/KgIntravenous Hot water tail flick test40% maximum possible effect after 5 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0086BVDO2DmtNmeAFS-NH8H-Dmt-Nme-D-Ala-Phe-Ser-NH2MethylationAmidationNA4TetrapeptideCationicNANANANANANAC57BL6 mice1 mg/KgIntravenous Hot water tail flick test80% maximum possible effect after 15 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0087BVDO2DmtNmeAFS-NH9H-Dmt-Nme-D-Ala-Phe-Ser-NH2MethylationAmidationNA4TetrapeptideCationicNANANANANANAC57BL6 mice1 mg/KgIntravenous Hot water tail flick test80% maximum possible effect after 30 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0088BVDO2DmtNmeAFS-NH10H-Dmt-Nme-D-Ala-Phe-Ser-NH2MethylationAmidationNA4TetrapeptideCationicNANANANANANAC57BL6 mice1 mg/KgIntravenous Hot water tail flick test90% maximum possible effect after 60 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0089BVDO2DmtNmeAFS-NH11H-Dmt-Nme-D-Ala-Phe-Ser-NH2MethylationAmidationNA4TetrapeptideCationicNANANANANANAC57BL6 mice1 mg/KgIntravenous Hot water tail flick test100% maximum possible effect after 120 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0090BVDO2DmtNmeAFS-NH12H-Dmt-Nme-D-Ala-Phe-Ser-NH2MethylationAmidationNA4TetrapeptideCationicNANANANANANAC57BL6 mice0.5 mg/KgIntravenous Hot water tail flick test10% maximum possible effect after 5 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0091BVDO2DmtNmeAFS-NH13H-Dmt-Nme-D-Ala-Phe-Ser-NH2MethylationAmidationNA4TetrapeptideCationicNANANANANANAC57BL6 mice0.5 mg/KgIntravenous Hot water tail flick test40% maximum possible effect after 15 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0092BVDO2DmtNmeAFS-NH14H-Dmt-Nme-D-Ala-Phe-Ser-NH2MethylationAmidationNA4TetrapeptideCationicNANANANANANAC57BL6 mice0.5 mg/KgIntravenous Hot water tail flick test70% maximum possible effect after 30 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0093BVDO2DmtNmeAFS-NH15H-Dmt-Nme-D-Ala-Phe-Ser-NH2MethylationAmidationNA4TetrapeptideCationicNANANANANANAC57BL6 mice0.5 mg/KgIntravenous Hot water tail flick test80% maximum possible effect after 60 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0094BVDO2DmtNmeAFS-NH16H-Dmt-Nme-D-Ala-Phe-Ser-NH2MethylationAmidationNA4TetrapeptideCationicNANANANANANAC57BL6 mice0.5 mg/KgIntravenous Hot water tail flick test30% maximum possible effect after 120 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0095BVDO3Dmt-N-Me-D-AAbaG-NH2Dmt-N-Me-D-Ala-Aba-Gly-NH2MethylationAmidationAddition of amiNAbenzoic acid at alanine4TetrapeptideCationicNANANANANANAC57BL6 mice4 mg/KgIntravenous Hot water tail flick test10% maximum possible effect after 5 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0096BVDO3Dmt-N-Me-D-AAbaG-NH3Dmt-N-Me-D-Ala-Aba-Gly-NH2MethylationAmidationAddition of amiNAbenzoic acid at alanine4TetrapeptideCationicNANANANANANAC57BL6 mice4 mg/KgIntravenous Hot water tail flick test40% maximum possible effect after 15 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0097BVDO3Dmt-N-Me-D-AAbaG-NH4Dmt-N-Me-D-Ala-Aba-Gly-NH2MethylationAmidationAddition of amiNAbenzoic acid at alanine4TetrapeptideCationicNANANANANANAC57BL6 mice4 mg/KgIntravenous Hot water tail flick test70% maximum possible effect after 30 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0098BVDO3Dmt-N-Me-D-AAbaG-NH5Dmt-N-Me-D-Ala-Aba-Gly-NH2MethylationAmidationAddition of amiNAbenzoic acid at alanine4TetrapeptideCationicNANANANANANAC57BL6 mice4 mg/KgIntravenous Hot water tail flick test70% maximum possible effect after 60 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0099BVDO3Dmt-N-Me-D-AAbaG-NH6Dmt-N-Me-D-Ala-Aba-Gly-NH2MethylationAmidationAddition of amiNAbenzoic acid at alanine4TetrapeptideCationicNANANANANANAC57BL6 mice4 mg/KgIntravenous Hot water tail flick test50% maximum possible effect after 120 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0100BVDO3Dmt-N-Me-D-AAbaG-NH7Dmt-N-Me-D-Ala-Aba-Gly-NH2MethylationAmidationAddition of amiNAbenzoic acid at alanine4TetrapeptideCationicNANANANANANAC57BL6 mice1 mg/KgIntravenous Hot water tail flick test10% maximum possible effect after 5 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0101BVDO3Dmt-N-Me-D-AAbaG-NH8Dmt-N-Me-D-Ala-Aba-Gly-NH2MethylationAmidationAddition of amiNAbenzoic acid at alanine4TetrapeptideCationicNANANANANANAC57BL6 mice1 mg/KgIntravenous Hot water tail flick test50% maximum possible effect after 15 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0102BVDO3Dmt-N-Me-D-AAbaG-NH9Dmt-N-Me-D-Ala-Aba-Gly-NH2MethylationAmidationAddition of amiNAbenzoic acid at alanine4TetrapeptideCationicNANANANANANAC57BL6 mice1 mg/KgIntravenous Hot water tail flick test70% maximum possible effect after 30 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0103BVDO3Dmt-N-Me-D-AAbaG-NH10Dmt-N-Me-D-Ala-Aba-Gly-NH2MethylationAmidationAddition of amiNAbenzoic acid at alanine4TetrapeptideCationicNANANANANANAC57BL6 mice1 mg/KgIntravenous Hot water tail flick test90% maximum possible effect after 60 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0104BVDO3Dmt-N-Me-D-AAbaG-NH11Dmt-N-Me-D-Ala-Aba-Gly-NH2MethylationAmidationAddition of amiNAbenzoic acid at alanine4TetrapeptideCationicNANANANANANAC57BL6 mice1 mg/KgIntravenous Hot water tail flick test90% maximum possible effect after 120 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0105BVDO3Dmt-N-Me-D-AAbaG-NH12Dmt-N-Me-D-Ala-Aba-Gly-NH2MethylationAmidationAddition of amiNAbenzoic acid at alanine4TetrapeptideCationicNANANANANANAC57BL6 mice0.5 mg/KgIntravenous Hot water tail flick test30% maximum possible effect after 5 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0106BVDO3Dmt-N-Me-D-AAbaG-NH13Dmt-N-Me-D-Ala-Aba-Gly-NH2MethylationAmidationAddition of amiNAbenzoic acid at alanine4TetrapeptideCationicNANANANANANAC57BL6 mice0.5 mg/KgIntravenous Hot water tail flick test40% maximum possible effect after 15 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0107BVDO3Dmt-N-Me-D-AAbaG-NH14Dmt-N-Me-D-Ala-Aba-Gly-NH2MethylationAmidationAddition of amiNAbenzoic acid at alanine4TetrapeptideCationicNANANANANANAC57BL6 mice0.5 mg/KgIntravenous Hot water tail flick test40% maximum possible effect after 30 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0108BVDO3Dmt-N-Me-D-AAbaG-NH15Dmt-N-Me-D-Ala-Aba-Gly-NH2MethylationAmidationAddition of amiNAbenzoic acid at alanine4TetrapeptideCationicNANANANANANAC57BL6 mice0.5 mg/KgIntravenous Hot water tail flick test90% maximum possible effect after 60 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0109BVDO3Dmt-N-Me-D-AAbaG-NH16Dmt-N-Me-D-Ala-Aba-Gly-NH2MethylationAmidationAddition of amiNAbenzoic acid at alanine4TetrapeptideCationicNANANANANANAC57BL6 mice0.5 mg/KgIntravenous Hot water tail flick test90% maximum possible effect after 120 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0110BVDO3Dmt-N-Me-D-AAbaG-NH17Dmt-N-Me-D-Ala-Aba-Gly-NH2MethylationAmidationAddition of amiNAbenzoic acid at alanine4TetrapeptideCationicNANANANANANAC57BL6 mice0.25mg/KgIntravenous Hot water tail flick test30% maximum possible effect after 5 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0111BVDO3Dmt-N-Me-D-AAbaG-NH18Dmt-N-Me-D-Ala-Aba-Gly-NH2MethylationAmidationAddition of amiNAbenzoic acid at alanine4TetrapeptideCationicNANANANANANAC57BL6 mice0.25mg/KgIntravenous Hot water tail flick test30% maximum possible effect after 15 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0112BVDO3Dmt-N-Me-D-AAbaG-NH19Dmt-N-Me-D-Ala-Aba-Gly-NH2MethylationAmidationAddition of amiNAbenzoic acid at alanine4TetrapeptideCationicNANANANANANAC57BL6 mice0.25mg/KgIntravenous Hot water tail flick test30% maximum possible effect after 30 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0113BVDO3Dmt-N-Me-D-AAbaG-NH20Dmt-N-Me-D-Ala-Aba-Gly-NH2MethylationAmidationAddition of amiNAbenzoic acid at alanine4TetrapeptideCationicNANANANANANAC57BL6 mice0.25mg/KgIntravenous Hot water tail flick test40% maximum possible effect after 60 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0114BVDO3Dmt-N-Me-D-AAbaG-NH21Dmt-N-Me-D-Ala-Aba-Gly-NH2MethylationAmidationAddition of amiNAbenzoic acid at alanine4TetrapeptideCationicNANANANANANAC57BL6 mice0.25mg/KgIntravenous Hot water tail flick test50% maximum possible effect after 120 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0115BVDO3H-Dmt-D-RAbaG-NH2H-Dmt-D-Arg-Aba-Gly-NH2MethylationAmidationAddition of amiNAbenzoic acid at arginine4TetrapeptideCationicNANANANANANAC57BL6 mice4 mg/KgIntravenous Hot water tail flick test30% maximum possible effect after 5 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0116BVDO3H-Dmt-D-RAbaG-NH3H-Dmt-D-Arg-Aba-Gly-NH2MethylationAmidationAddition of amiNAbenzoic acid at arginine4TetrapeptideCationicNANANANANANAC57BL6 mice4 mg/KgIntravenous Hot water tail flick test100% maximum possible effect after 15 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0117BVDO3H-Dmt-D-RAbaG-NH4H-Dmt-D-Arg-Aba-Gly-NH2MethylationAmidationAddition of amiNAbenzoic acid at arginine4TetrapeptideCationicNANANANANANAC57BL6 mice4 mg/KgIntravenous Hot water tail flick test100% maximum possible effect after 30 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0118BVDO3H-Dmt-D-RAbaG-NH5H-Dmt-D-Arg-Aba-Gly-NH2MethylationAmidationAddition of amiNAbenzoic acid at arginine4TetrapeptideCationicNANANANANANAC57BL6 mice4 mg/KgIntravenous Hot water tail flick test100% maximum possible effect after 60 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0119BVDO3H-Dmt-D-RAbaG-NH6H-Dmt-D-Arg-Aba-Gly-NH2MethylationAmidationAddition of amiNAbenzoic acid at arginine4TetrapeptideCationicNANANANANANAC57BL6 mice4 mg/KgIntravenous Hot water tail flick test100% maximum possible effect after 120 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0120BVDO3H-Dmt-D-RAbaG-NH7H-Dmt-D-Arg-Aba-Gly-NH2MethylationAmidationAddition of amiNAbenzoic acid at arginine4TetrapeptideCationicNANANANANANAC57BL6 mice1 mg/KgIntravenous Hot water tail flick test30% maximum possible effect after 5 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619